A European position on genome editing

ASHG POSITION STATEMENT Human Germline Genome Editing

With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017. The workgroup included representatives from the UK Association of Genetic Nurses and Counsellors, Canadian Associatio...

A European perspective on the position papers.

Our comments begin with a short review of some of the differences in narratives concerning the history and the origin of humanistic psychology (HP) between the United States-portrayed in several of the position papers-and Europe. Second, we discuss the effectiveness and conceptual understanding of HP and its implication for training. Third, we make reference to humanistic therapeutic goals and ...

Genome Editing



[Scientific review on novel genome editing techniques].

背 景 次世代遺伝子組換え技術とは,欧州のJoint Research Center (JRC)が報告して以来novel plant breeding techniques (NPBTまたはNBTと略される)と呼ばれて いる新規の植物育種方法である.痕跡が残らない遺伝子組 換え法としてすでに新聞報道もされている.これらの技術 の一部は植物だけでなく動物にも用いられていることか ら,NPBTという名称は正確ではない.そのため,本総説 では次世代遺伝子組換え技術(以下,次世代組換え技術と する). 従来の遺伝子組換え作物は,優れた形質を発現させるた めに外来遺伝子を異なる生物種から分離してベクターへ組 込み後,細胞へ遺伝子導入(transfection)することによ り作出されてきた.このとき,ゲノム上にランダムに挿入 されたものの中から,望む形質のみを示すものを選抜す る.こうして得ら...

Advancing Chimeric Antigen Receptor-Engineered T-Cell Immunotherapy Using Genome Editing Technologies: Challenges and Future Prospects

Chimeric antigen receptor engineered-T (CAR-T) cells also named as living drugs, have been recently known as a breakthrough technology and were applied as an adoptive immunotherapy against different types of cancer. They also attracted widespread interest because of the success of B-cell malignancy therapy achieved by anti-CD19 CAR-T cells. Current genetic toolbox enabled the synthesis of CARs ...